KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K12
All Species:
10.61
Human Site:
S735
Identified Species:
19.44
UniProt:
Q12852
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12852
NP_006292.2
859
93219
S735
S
E
V
E
L
T
S
S
Q
R
W
P
Q
S
L
Chimpanzee
Pan troglodytes
XP_509099
871
93967
Q746
R
A
A
V
T
R
S
Q
V
K
W
P
Q
S
L
Rhesus Macaque
Macaca mulatta
XP_001105474
890
96134
S765
S
E
V
E
L
T
S
S
Q
R
W
P
Q
S
L
Dog
Lupus familis
XP_857182
860
93116
S735
S
E
V
E
L
T
S
S
Q
R
W
P
Q
G
L
Cat
Felis silvestris
Mouse
Mus musculus
Q60700
888
96066
E762
E
E
G
E
V
D
S
E
V
E
L
P
P
S
Q
Rat
Rattus norvegicus
Q63796
888
96289
P766
V
D
S
E
V
E
L
P
P
S
Q
R
W
P
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422689
966
107967
R821
S
E
V
E
F
P
R
R
Q
R
P
H
R
C
I
Frog
Xenopus laevis
A7J1T0
961
107551
R831
S
E
V
E
F
P
R
R
H
R
P
P
R
G
M
Zebra Danio
Brachydanio rerio
NP_996977
856
94429
R723
E
V
E
L
P
R
R
R
R
P
T
S
I
T
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95UN8
1161
128942
P967
E
P
D
F
V
A
T
P
R
T
T
A
R
S
D
Honey Bee
Apis mellifera
XP_397605
895
101116
C753
S
E
N
K
T
R
P
C
S
E
S
M
D
T
L
Nematode Worm
Caenorhab. elegans
O01700
928
103465
I782
S
D
V
T
M
N
P
I
Y
T
S
P
I
T
T
Sea Urchin
Strong. purpuratus
XP_795085
943
105022
S806
T
K
S
S
L
E
K
S
K
G
G
E
S
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.7
95.2
97.4
N.A.
92.5
91.7
N.A.
N.A.
52.3
51.8
65.4
N.A.
24
38.4
29
38.6
Protein Similarity:
100
95.8
95.6
98.5
N.A.
93.8
93.1
N.A.
N.A.
62.5
63.1
74
N.A.
38.4
52.8
44.9
52.8
P-Site Identity:
100
40
100
93.3
N.A.
33.3
6.6
N.A.
N.A.
40
40
0
N.A.
6.6
20
20
20
P-Site Similarity:
100
46.6
100
93.3
N.A.
40
20
N.A.
N.A.
53.3
53.3
13.3
N.A.
33.3
33.3
40
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
0
0
8
0
0
0
0
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
8
0
% C
% Asp:
0
16
8
0
0
8
0
0
0
0
0
0
8
0
8
% D
% Glu:
24
54
8
54
0
16
0
8
0
16
0
8
0
0
0
% E
% Phe:
0
0
0
8
16
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
0
0
0
0
0
0
8
8
0
0
16
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
8
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
8
0
0
0
0
16
0
8
% I
% Lys:
0
8
0
8
0
0
8
0
8
8
0
0
0
0
8
% K
% Leu:
0
0
0
8
31
0
8
0
0
0
8
0
0
0
39
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
8
0
0
8
% M
% Asn:
0
0
8
0
0
8
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
8
0
0
8
16
16
16
8
8
16
54
8
8
0
% P
% Gln:
0
0
0
0
0
0
0
8
31
0
8
0
31
0
16
% Q
% Arg:
8
0
0
0
0
24
24
24
16
39
0
8
24
0
0
% R
% Ser:
54
0
16
8
0
0
39
31
8
8
16
8
8
47
8
% S
% Thr:
8
0
0
8
16
24
8
0
0
16
16
0
0
24
8
% T
% Val:
8
8
47
8
24
0
0
0
16
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
31
0
8
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _